The movie received mixed reviews from critics and audiences. Some reviewers praised the film's lighthearted and comedic approach, while others felt it didn't live up to the original franchise's standards.

According to Box Office Mojo, "American Pie Presents: Girls' Rules" grossed approximately $19.7 million worldwide on a budget of $5 million.

The film was released on August 14, 2020, on Netflix. The marketing campaign focused on social media promotions, targeting the film's core audience: teenagers and young adults.